The role of skeletal muscle in glucose transport, glucose homeostasis, and insulin resistance: implications for physical therapy.

The Role of Skeletal Muscle in Glucose Transport, Glucose Homeostasis, and Insulin Resistance: Implications

Simultaneous Effect of Resistance Training and Stem Cell Injection on Blood Glucose Levels, Insulin Resistance, Caspase 3 And 7 As Indicators of Skeletal Muscle Apoptosis in STZ-Induced Male Diabetic Rats

Background: The aim of the present study was to investigate the simultaneous effect of resistance training and stem cell injection on the levels of some indicators of skeletal muscle apoptosis in STZ-induced diabetic male rats. Methods: In this study, 30 rats were randomly divided into 5 groups. Rats in the diabetic group and the diabetic group + stem cell injection had a total of 17 sessions...

Conjugated linoleic acid supplementation enhances insulin sensitivity and peroxisome proliferator-activated receptor gamma and glucose transporter type 4 protein expression in the skeletal muscles of rats during endurance exercise

Objective(s):This study examined whether conjugated linoleic acid (CLA) supplementation affects insulin sensitivity and peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 4 (GLUT-4) protein expressions in the skeletal muscles of rats during endurance exercise. Materials and Methods:Sprague-Dawley male rats were randomly divided into HS (high-fat diet (HFD) s...

Simultaneous Effect of Resistance Training and Stem Cell Injection on Blood Glucose Levels and Bax and Bcl2 Protein Expression from Markers of Skeletal Muscle Apoptosis in STZ-Induced Diabetic Male Rats

Background: Type 1 diabetes is a disorder caused by autoimmune destruction of pancreatic insulin-producing cells. This induction of autoimmunity may be due to genetic and environmental factors. Bax and Bcl2 proteins play an important role in the process of apoptosis. Methods: In this study, 30 male Wistar rats weighting approximately 200±20gr were randomly selected from available rats in lab ...

Regulation of glucose transport in human skeletal muscle.

Glucose transport, the rate limiting step in glucose metabolism in skeletal muscle, is mediated by insulin-sensitive glucose transporter 4 (GLUT4) and can be activated in skeletal muscle by two separate and distinct signalling pathways: one stimulated by insulin and the second by muscle contractions. Skeletal muscle is the principal tissue responsible for insulin-stimulated glucose disposal and...